Fig. 4.
Effect of Desferal on cell killing induced by chemotherapy drugs in the presence and absence of H2O2.
After a 1-hour preincubation with Desferal (10 μmol/L), cells were treated for 22 hours with 1.7 μmol/L VP-16, 0.2 μmol/L doxorubicin, or 50 μmol/L cisplatin in the presence or absence of 50 μmol/L H2O2 (added 30 minutes after the chemotherapy drugs) and analyzed as described in the legend to Figure 2. Pyknotic/necrotic cells are indicated by ▪, and apoptotic cells are indicated by □.
