Fig. 1.
![Fig. 1. BPI inhibits proliferation of HUVECs. / (A) Proliferation was measured after 72 hours of culture in the presence of 0.18, 0.54, or 1.8 μmol/L BPI by analysis of [3H]-thymidine incorporation. (B) Cell death induced by BPI, PF4, or BSA, or after starvation by culture in the presence of low serum concentrations (1%), as determined by trypan blue exclusion. (C) Comparison of proliferation inhibition by BPI (n = 4) and PF4 (n = 9), plotted as percentage of thymidine incorporation under control conditions. In panel A and B, the results of 3 independent experiments performed in triplicate are shown (*P < .05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/1/10.1182_blood.v96.1.176/4/bloo01332001x.jpeg?Expires=1735561636&Signature=M~TVqGnlbUPUQroqLzNFx-WoGSK~sWJaGEuAOFsEamE~ItK-UFlbBrVk8OmdOtTBf7ahWS1ZxHIRRTIekbrEc8I~ixo0g503IxsCGBdF0GZuidPwJY4jkx6jow5muQzxlyVBv2~eSPfhgHRSDtYIBhrSlXFICMyuOncf-D62rSH3L~nRb5DsMjGeecnPw96TlVRenfzWaMPp9ei-Dss2vUd0yXzTRlcI4RyQUd~BDybWc3wLMNnilpMPWERNUTo0hXgIdwltfxlaVTKNTJ5yVOTb8o1BMdHKZ5zX1dJo1Ov2zO1ygjqeycz0IieG8aq9AClU~JtpQU0SVBUptzgnHQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
BPI inhibits proliferation of HUVECs.
(A) Proliferation was measured after 72 hours of culture in the presence of 0.18, 0.54, or 1.8 μmol/L BPI by analysis of [3H]-thymidine incorporation. (B) Cell death induced by BPI, PF4, or BSA, or after starvation by culture in the presence of low serum concentrations (1%), as determined by trypan blue exclusion. (C) Comparison of proliferation inhibition by BPI (n = 4) and PF4 (n = 9), plotted as percentage of thymidine incorporation under control conditions. In panel A and B, the results of 3 independent experiments performed in triplicate are shown (*P < .05).
