Fig. 4.
Estrogen stimulation of granulocyte NO release by E2-BSA is not antagonized by 10−8 mol/L ICI 182,780.
E2-BSA (10−9 mol/L) stimulates NO release from granulocytes within 2 minutes of its application, and this release is not antagonized by ICI 182,780 (ICI), an antiestrogen nuclear binding protein. ICI 182,780 was added to the milieu at 0 minutes, and E2-BSA was added at a 2-minute interval. Each experiment was repeated 4 times, and the resulting mean value plus or minus SEM was graphed.
