Number of T/NK cells after IT combination treatment.

Patients 1 (▴) and 4 (○) received 3 and patient 3 (▪) received all of the 4 planned IT combination doses, given as 4-hour infusions at 48-hour intervals. The arrow beneath the x axis indicates the start of the first infusion. T/NK cells were identified by being CD2⁺ or CD5⁺ or both. Their number was expressed as percentage relative to the concentration at start of therapy (being 0.7, 1.0, and 0.2 × 10⁹ cells/L for patients 1, 3, and 4, respectively). The inlay figure represents the amount of T/NK cells of patient 3 as determined over a longer period.