Fig. 4.
Fig. 4. Anticoagulant activity of mutants 306/312AA-APC and 306-314AAAA-APC versus wild-type APC. / (A) Normal human plasma: wild-type APC (+), 306A/312AA-APC (○), 306A-314AAAA-APC (▵). (B) Q506-FV human plasma: wild-type APC (+), 306A/312AA-APC (○), 306A-314AAAA-APC (▵). APTT assays were performed using plasma mixtures containing 10% normal human plasma or 10% Q506-FV human plasma as described above. Data shown are the average of 4 experiments for each line and SDs are shown as error bars.

Anticoagulant activity of mutants 306/312AA-APC and 306-314AAAA-APC versus wild-type APC.

(A) Normal human plasma: wild-type APC (+), 306A/312AA-APC (○), 306A-314AAAA-APC (▵). (B) Q506-FV human plasma: wild-type APC (+), 306A/312AA-APC (○), 306A-314AAAA-APC (▵). APTT assays were performed using plasma mixtures containing 10% normal human plasma or 10% Q506-FV human plasma as described above. Data shown are the average of 4 experiments for each line and SDs are shown as error bars.

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