Effects of anti-MIP-1 on OCL formation induced by marrow plasma from patients with MM

. Marrow plasma and marrow cultures were processed as described. Anti-MIP-1α at a concentration of 3 ng/mL, which neutralized up to 10 ng/mL of MIP-1α, blocked the OCL formation induced by the bone marrow plasma of 2 patients with MM in human bone marrow cultures. Results represent the mean ± SEM for a typical experiment. A similar pattern of results was seen in cultures from a total of 5 of 6 myeloma marrow plasma samples.