Effect of ADP antagonists ARL 66096 and A3P5PS on plasma platelet aggregation induced by SDF-1 and MDC.

Platelets in PRP were preincubated with a specific ADP antagonist and stimulated with 100 nmol/L MDC. (A) The second wave of MDC-induced platelet aggregation was inhibited by 1 μmol/L ARL 66096, (B) while 100 μmol/L A3P5PS had only a slight inhibitory effect. In contrast, aggregation induced by SDF-1 is only slightly affected by (C) ARL 66096 or (D) A3P5PS.