Anti-VEGFR-3 suppresses the growth of C6 tumor cells implanted subcutaneously in nude mice.

(A) Protocol 1: days 0 to 12. Alternate-day treatment with PBS (n = 8), anti-VEGFR-2 (600 μg/dose; n = 4), or anti-VEGFR-3 (200 μg/dose, 600 μg/dose, 1000 μg/dose; n = 4 each). Tumor size at day 14 was summarized in Table 1. (B) Protocol 2: days 0 to 6. Injection of anti-VEGFR-3 treatment (600 μg/dose, closed circle; n = 4), compared with continuous injection (days 0-12) (open circle; n = 4). (C) Protocol 3: days 7 to 13. Anti-VEGFR-3 treatment (600 μg/dose, closed circle; n = 4) and PBS treatment (open circle; n = 4). The growth curves of tumors in PBS-treated mice were used as reference points for each figure.