T-cell development in FTOC from progressors and LTNPs.

(A) CD4 and CD8 expression of cells from FTOC of samples taken during the course of infection for a representative LTNP (top panels) and progressor (bottom panels). (B) Shown is the mean (± SEM) number of CD4⁺, CD8⁺, and double-positive cells per lobe per 10 000 cells in the original inoculum that developed in FTOC. Pre-seroconversion (▪) and the last post-seroconversion sample tested (□), at AIDS diagnosis for progressors and 8 years post-seroconversion for LTNPs, are depicted. P values were calculated with Mann–Whitney U test between the groups and by Wilcoxon signed rank test within the groups. (C) Longitudinal data for CD4⁺ and CD8⁺ development in FTOC for all progressors (open squares) and LTNPs (closed circles) combined. Time 0 is the pre-seroconversion sample taken at least 1 year before seroconversion. P values were calculated with repeated-measures ANOVA. *P < .001. For the LTNP group, all patients are represented at all time points (n = 7). For the progressor group, patients were eliminated from the study with AIDS diagnosis; therefore, for time points 0, 0.5, and 2 (n = 7), for time point 4 (n = 6), for time point 6 (n = 5), and for time point 8 (n = 2).