Development of T cells in FTOC for participants in therapy trials.

(A) CD4⁺ and CD8⁺ T-cell development before the start of therapy (□) and after 6 months of therapy (▪) for all 18 participants. P values were calculated using Wilcoxon signed-rank test. *P < .001; **P < .005. (B) Correlation analysis for change in number of naive cells in peripheral blood and the change in the development of cells in FTOC. Graphs show the changes in naive CD4⁺ and CD8⁺ T cells in peripheral blood in the first 6 months of therapy compared with the changes in the development of CD4⁺ and CD8⁺cells in FTOC during the same period for all participants in the therapy trials. Correlations and P values were determined using the Spearman rank correlation test.