Pedigree of the Norwegian family with congenital afibrinogenemia showing the consanguineous lineage of both parents.

Coagulation parameters shown below the symbols are, in order from the top, functional fibrinogen (mg/mL), thrombin clotting times, and reptilase clotting times. Deceased individuals are crossed by a diagonal line. Hatched symbols denote individuals who were not investigated. Deceased individuals I:1, I:3, and I:5 are presumed carriers (half-hatched symbols) because of the normal coagulation values for individuals I:2 and I:6. Open, half-filled, and filled symbols denote genotypically normal, heterozygous, and homozygous individuals, respectively, on the basis of the BsrDI assay.