Iron deposition in tissues from wild-type andTrf^hpx/hpx mice.

Histologic sections were stained with the Perl's stain for iron. Panels A, C, and E are sections of liver, kidney, and heart (respectively) from nonanemic mice (Trf^hpx/+ orTrf^+/+ genotype). Panels B, D, and F are sections of liver, kidney, and heart fromTrf^hpx/hpx mice. Iron deposits stain blue. The arrow in panel B highlights an area of extramedullary hematopoiesis within the liver of the mutant animal.