Mutation events of BCL-6 in FCL transformation.

Mutation events in the 5′ noncoding regulatory region of the BCL-6 gene derived from biopsy specimens at the time of FCL diagnosis (IL114A), FCL relapse (IL114B), and transformation to DLBCL (IL114C) in NHL patient IL116. Clonal relationship of the molecular clone sequences (ovals) is shown. Number of mutations is indicated along the lines in bold. The mutations are listed by location as is specified in the “Materials and methods.”