TEL/AML1 and in vitro drug resistance for ASP, PRED, and VCR.

Relation between TEL/AML1 and in vitro drug resistance for ASP (A), PRED (B), and VCR (C) in childhood c/preB ALL. LC₅₀ values for c/preB, older than 12 months, non-hyperdiploid (> 50 chromosomes), non-Philadelphia translocation TEL/AML1-negative versus TEL/AML1-positive patients. Boxes represent the 25th to the 75th percentiles with the median, shown as a horizontal bar. Whiskers give the minimum and maximum values. LC₅₀ values are expressed as μg/mL; those for ASP are expressed as IU/mL. P values were determined by the Mann–Whitney U test.