Staining for CD4 and CD8 in spleen from case 2.

(A) The lymphoid infiltrate in the spleen is predominantly CD8⁺. (B) Staining for CD4 highlights erythrophagocytic histiocytes, whereas the lymphocytes are negative. (C) The small lymphocytes express TIA-1. (D) They are BF1⁺ and are strongly EBER-1⁺ (E) (immunoperoxidase stained, hematoxylin counterstained, × 200).