Chemokine receptor expression in ALCL.

(A) Tumor shows a diffuse infiltrate of anaplastic cells with cytoplasmic and nuclear reactivity for ALK (inset). CD30 was uniformly positive (not shown). (B) Immunostain for CCR4 shows membrane and granular cytoplasmic reactivity in all tumor cells. Admixed small lymphocytes are negative. Immunostain for the CCR4 ligand TARC shows staining of intratumoral blood vessels; tumor cells are negative (inset). (C) Immunostain for CXCR3 is negative in tumor cells.