Chemokine receptor expression in cutaneous lymphoma.

(A) Patch-stage MF with an epidermotropic and superficial dermal infiltrate showing CXCR3 reactivity. CCR4 immunostain was negative (not shown). (B) Cutaneous lymphoma with slack skin presentation shows reactivity of the large epidermotropic tumor cells for CCR4. CXCR3 immunostain was negative (not shown). (C) Nodal large-cell transformation of MF. Large tumor cells show diffuse reactivity for CCR4; CXCR3 was positive only in admixed small lymphocytes (not shown). (D) Increased MCP-2 in stromal cells in lymph node involvement by MF. Interfollicular macrophages and nontumor mononuclear cells show MCP-2 expression in 4 of 4 patients with nodal involvement by low-grade MF. Increased MCP-2 was not seen in nodal involvement by transformed MF (not shown).