Variability of chemokine receptor and TNF receptor expression in nodal T-cell lymphoma.

(A) Nodal peripheral T-cell lymphoma with a predominant large-cell morphology showing diffuse membrane and cytoplasmic reactivity for CCR4 in most tumor cells. CD30 immunostain is negative (inset). (B) Nodal peripheral T-cell lymphoma with a predominant large-cell morphology showing diffuse reactivity for CXCR3; CD134/OX40 immunostain was also diffusely positive (inset). (C, D) Angioimmunoblastic T-cell lymphoma in lymph node. CD134/OX40 immunostain highlights clusters of OX40-positive larger tumor cells (C). CXCR3 immunostain is diffusely positive in small- to intermediate-sized lymphocytes from the same biopsy (D). Large, clear cells are variably positive.