The p210 BCR/ABL Y177F and v-abloncogenes are defective for the induction of CML-like disease in mice.

Kaplan–Meier-style survival curve for recipients of bone marrow from 5-FU–treated donors transduced with the indicated ABLoncogene. The symbols in each curve designate individual mice (n = 15 for P210 WT, n = 10 for P210 Y177F, and n = 10 for v-abl). Solid black symbols, CML-like disease; open symbols, B-lymphoid leukemia; light gray symbols, macrophage disease; dark gray symbols, mast cell disease; hatched symbols, T-lymphoid leukemia. Animals diagnosed with 2 or more disease processes simultaneously, based on histopathologic and molecular analysis (see text), are indicated by multi-shaded symbols. The difference in survival between recipients of p210 WT-transduced marrow and either p210 Y177F- or v-abl–transduced marrow was highly significant (P < .0001, Mantel-Cox test). One recipient of v-abl-transduced marrow died 285 days after transplantation of nonleukemic causes. Asterisks indicate mice with increased peripheral blood neutrophils (see text).