Fig. 5.
Fig. 5. STI 571 inhibits c-kit–dependent activation of MAP kinase in HMC-1 cells. / HMC-1 cells were treated with various concentrations of STI 571 for 90 minutes. Whole cell lysates were immunoblotted with an antibody specific for phospho-MAP kinase. The membrane was stripped and reprobed with an antibody for total p44 and p42 MAP kinase. The arrows indicate the locations of p44 and p42 MAP kinase. Representative results from 1 of 8 independent experiments are shown.

STI 571 inhibits c-kit–dependent activation of MAP kinase in HMC-1 cells.

HMC-1 cells were treated with various concentrations of STI 571 for 90 minutes. Whole cell lysates were immunoblotted with an antibody specific for phospho-MAP kinase. The membrane was stripped and reprobed with an antibody for total p44 and p42 MAP kinase. The arrows indicate the locations of p44 and p42 MAP kinase. Representative results from 1 of 8 independent experiments are shown.

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