Fig. 7.
STI 571 inhibits c-kit–dependent activation of Akt in HMC-1 cells.
Whole cell lysates of M-07e cells were prepared and immunoblotted with a polyclonal antibody specific for Akt protein that had been activated by phosphorylation of serine 473. The membrane was stripped and reprobed with an antibody to total Akt. Representative results from 1 of 8 independent experiments are shown.