STI 571 inhibits proliferation of HMC-1 cells.

HMC-1 cells were plated in 96-well plates at a concentration of 20 000 cells/well and cultured in RPMI-1640 supplemented with 10% FCS with and without various concentrations of STI 571. Cellular proliferation at 48 hours was measured with an XTT-based assay system. Results are expressed as the percentage of maximal proliferation (cells only; no STI 571) (± SD). Representative results from 1 of 6 independent experiments are shown.