The effect of donor CD4⁺ cell and MHC class II expression on persistence of donor cells and alloantibody production.

DBA/2 recipient mice were injected intravenously with 1 spleen equivalent of FITC labeled splenocytes from C57BL/6 (□), CD4 KO (◊), MHC II KO (○) donor mice and then the spleen and plasma were obtained from the recipient mice on the indicated days. Persistence of donor cells in the spleen (panel A) and alloantibody levels in the plasma (panel B, mean of 2 to 7 mice per point) are shown.