Comparative effects of homocysteine and methionine on the expression of tissue factor by PBMC.

Experiments in this figure were conducted with the PBMC cultured in RPMI 1640 lacking methionine. Results shown are the geometric mean ± SEM of the thromboplastin activity of PBMCs from 3 donors. (A) Effect of methionine replacement on the tissue factor expression in the presence of buffer, LPS, or homocysteine. Met, methionine. (B) Dose-response curve to homocysteine (▪)and methionine (•) (P <  .001 and P  <  .02 for trend, respectively).