Family pedigree.

The bold arrow indicates the proband. Roman numerals to the left of the figure indicate the generation, and Arabic numerals above each symbol indicate the family member. The right side of the symbol is black for family members who have experienced venous thrombosis. The left half of the symbol is gray for family members heterozygous for the fibrinogen Paris V mutation. The asterisk below the symbol indicates that DNA was available for identification of the fibrinogen Paris V mutation. A diagonal slash through the symbol indicates death, and a double slash indicates that death was from pulmonary embolism. It is possible that patient IV.3 died from a pulmonary embolus; however, this was not established during the hospital stay, and no autopsy was performed.