Multicolor banding of chromosome 5 in the t(5;17) cases.

(A) Case 54: insertion of the 5q13 band into band 3q26 and translocation of segment 5q34-qter to band 17q21. Figure shows the translocation of 17q to the der(5q). Left panel: top, DAPI filter; middle, compilation of captures with each filter excluding the DAPI one; bottom, multicolor banding specific for chromosome 5 material obtained after image processing. Right panel: profile of fluorescence intensities along the chromosomal axes. Peaks on der(3) and der(17) are derived from chromosome 5 material. (B) Case 55: localization of the 5q breakpoint to 5q13. Analysis as described in panel A. (C) Location and labeling of chromosome 5 region–specific partial chromosome paints; breakpoints in case 54 (▵) and in case 55 (▴) are shown.