Ribbon diagrams of the C domains: localization of hemophilic mutations.

Sites of hemophilic mutations (Table 3) are shown as spheres at the positions of their Cα atoms in the protein structure in stereo views. Spheres are color-coded according to the reported severity; lighter lavender represents mild to moderately severe, and darker violet represents more severe phenotypes (as reported for at least one affected individual). Core β-strands are green (foreground) and red (opposite side) ribbons with additional strands blue; each pair is oriented as in Figure 2. (A) The C1 model is based on homology modeling against the C2-domain crystal structure as described in Figure 2 and the text. (B) C2 is from the previously described crystal structure.22