The in vivo effect of SS2 administration on GVHD induced across the MHC class II barrier in bm12 recipients of C57BL/6 T cells.

Irradiated (6 Gy) recipients were given enriched LN T cells. Groups of mice (n = 6 per group) received BID ip injections of SS2 at 40 μg/d administered for 1 day, monomer at its MTD of 10 μg/d for 4 days, or were untreated. (A) Data are represented as actuarial survival versus time in days. Statistical analysis indicated that the SS2 group differed significantly (P = .009) from the monomer group, the SS2 group differed significantly (P = .00062)) from the untreated group, and the monomer group differed significantly (P = .015) from the untreated group. (B) For these same mice, mean weights were plotted versus time. Standard deviation did not exceed 29% of the mean. On days 14 to 25, mean weights for the SS2 group differed significantly (P < .008) from the monomer group. † Untreated mice all died by day 18.