Fig. 6.
![Fig. 6. The MEKK1-JNK1 pathway is required for uPA induction by MNNG. / Effect of inhibitors of the JNK and p38 MAPK pathways on the activation of the murine uPA promoter by MNNG. C2C12 cells were transiently transfected with the p-6.6Luc reporter plasmid, together with expression vectors for dominant negative MEKK1, MKK7, SEK1 or MKK6b (MEKK1[K432M], MKK7[A], SEK1[KR], and MKK6b[A], respectively), as well as JIP-1, or vector alone. Luciferase activities are expressed relative to the activity of p-6.6Luc in unstimulated C2C12 cells, which has been given an arbitrary value of 1. Results obtained represent the average of at least 3 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/4/10.1182_blood.v96.4.1415/4/h81600059006.jpeg?Expires=1735547720&Signature=Fo7C38eU3FDb2pTZoxv1YXWanPMazaMhQOlgxMIdWWwwuBYh3~UcmUpdyFMASzLBQdpIS4knjmzTBJB8W8AOhQA9oSkxu~npWrRMlPcfLPHPMHVl2Sdah8tbaxks~Jgv3WLFxihYjLIMFV5BHvwb0Cfz7j4vg1Nex3cmyEumq7V~kqz5qlyxgx2jMtyIJsmd80Eup3MqQMxEuMtAjvPE0K8yt-zB2tFgfcLvsoChNiaO3c3EnFckjqPoEO4y2LhUEknNAeKuQtq0yDaZEMYbs0pZo~VOeegZDeOm4uMXEmmjnPpNT6Zj1wb2Ea6b7UkrRZGmjbYFt1YhzX3RmSpWnQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The MEKK1-JNK1 pathway is required for uPA induction by MNNG.
Effect of inhibitors of the JNK and p38 MAPK pathways on the activation of the murine uPA promoter by MNNG. C2C12 cells were transiently transfected with the p-6.6Luc reporter plasmid, together with expression vectors for dominant negative MEKK1, MKK7, SEK1 or MKK6b (MEKK1[K432M], MKK7[A], SEK1[KR], and MKK6b[A], respectively), as well as JIP-1, or vector alone. Luciferase activities are expressed relative to the activity of p-6.6Luc in unstimulated C2C12 cells, which has been given an arbitrary value of 1. Results obtained represent the average of at least 3 independent experiments.
