Genotyping results and comparative mapping of

Rw in rat, mouse, and human. (A) Haplotypes and their respective frequencies. Black boxes represent WAS-derived alleles, white boxes a combination of the wild-derived allele with a WAS allele. Haplotype frequencies are given underneath each column (n = 67). LOD scores are presented on the right panel. (B) The distal q-arm of rat Chr 1 containing Rw, and its orthologs in mouse and human. The map interval containing Rw is shaded in gray. In the rat, map distances and their corresponding 95% CI are given in cM. The centromere is depicted as a black circle, and broken double lines separate linkage groups. In the mouse, chromosomal assignments are noted in boldface, and locus positions are given in cM (in brackets). In humans, chromosomal assignments are denoted as above, but locus positions are as in the cytogenetic human genome map.1 indicates allelic heterogeneity between laboratory and wild strain;2, conflicting information on chromosomal location of Cyp2e1, see references 8 and 9.