Fibrinolytic activity of scuPA and scuPA/suPAR in uPA

^−/−mice in vivo. We infused uPA^−/− mice with scuPA (■) or scuPA/suPAR (▩) (0.25 or 0.5 mg scuPA/kg/h) via the jugular vein. Five minutes later,¹²⁵I-fibrin microparticles were injected, and the infusion of scuPA or scuPA/suPAR was continued for another hour. The lungs were harvested, washed, and counted for radioactivity. The data are expressed relative to fibrinolytic activity in WT mice infused with PBS in the same manner for 1 hour, as defined in “Materials and methods.” The means plus or minus SEM of 2 experiments, each involving data from 3-5 mice in each experimental group, are shown.