The role of STAT proteins in mediating the toxicity of IL-18 plus IL-12.

(A) STAT4^−/− (▵) mice and B6 x 129 background control mice (●) received daily injections of IL-18 and IL-12 via the IP route and were monitored for toxicity. (B) STAT1^−/− (▵) mice and C57BL/6 control mice (●) received daily injections of IL-18 and IL-12 via the IP route and were monitored for toxicity. Both experiments were repeated once with similar results.