Functional maturation accompanies CD8 induction on migratory LC.

Mice were immunized intradermally with ovalbumin and then painted with FITC. Twenty-four hours later FITC⁺CD8⁺CD11c⁺ and FITC⁺CD8⁻CD11c⁺ cells in the draining LN were isolated and tested for their ability to stimulate 2 × 10⁵ allogeneic T cells (A) and to process and present antigen to 5 × 10⁴ class I MHC-restricted, ovalbumin-specific T hybridoma cells. (B). Results shown are representative of 2 separate experiments.