Fig. 5.
Increased peripheral blood monocyte chemotaxis and receptor signaling by CD26/DPP IV–processed LD78β.
LD78α (♦), intact LD78β (▴), and truncated LD78β(3-70) (●) were tested (A) at different concentrations in the Boyden chamber chemotaxis test and (B) for their ability to increase the [Ca++]i on freshly isolated PBMCs. Chemotaxis results are expressed as the mean chemotactic index plus or minus SEM of 3 or more independent experiments. The detection limit for a significant increase in [Ca++]i is indicated by the dashed line. One representative experiment of 3 is shown in panel B.