Effect of soluble C-4S, DS, and C-6S on the capacity of hIL-10 to up-regulate the expression of CD64 and CD16 on monocytes/macrophages.

PBMC were stimulated with hIL-10 in the presence or absence of increasing concentrations of C-4S (▪), DS (♦), or C-6S (▴) for 24 hours. After the incubation period, CD64 (A) and CD16 (B) expression on monocytes/macrophages were determined as described in Figure 3. Data are presented as percentage inhibition of CD16 and CD64 induced by optimal concentration of hIL-10 (10 ng/mL) ± 2 SD. Data are representative of 2 separate experiments.