American Society of Hematology

Fig. 3.

$Fig. 3. Methotrexate resistance of mice preconditioned with 1 Gy TBI and transplanted with line 04 DHFR transgenic marrow. / Male mice were given 1 Gy TBI one day before transplantation with no marrow, 1 × 107 female normal (APP) marrow cells, or 1 × 107 female transgenic DHFR (Tg04) marrow cells. The animals were then administered either PBS or MTX (final dose of 4 mg/kg) intraperitoneally daily for 60 days (n = 10 for each group). (A) Kaplan–Meier plot showing the fraction of surviving mice per time in the MTX-administered groups. (B) Mean weekly hematocrit of surviving mice in the MTX-administered groups at each time point.$

Methotrexate resistance of mice preconditioned with 1 Gy TBI and transplanted with line 04 DHFR transgenic marrow.

Male mice were given 1 Gy TBI one day before transplantation with no marrow, 1 × 10⁷ female normal (APP) marrow cells, or 1 × 10⁷ female transgenic DHFR (Tg04) marrow cells. The animals were then administered either PBS or MTX (final dose of 4 mg/kg) intraperitoneally daily for 60 days (n = 10 for each group). (A) Kaplan–Meier plot showing the fraction of surviving mice per time in the MTX-administered groups. (B) Mean weekly hematocrit of surviving mice in the MTX-administered groups at each time point.

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