Fig. 2.
The effect of the IL-5 transgene on eosinophils in wild-type or eotaxin-deficient mice.
Eosinophils were quantitated in the blood (A) and Peyer's patches (B) of wild-type, IL-5–transgenic (Tg), and eotaxin-deficient (−/−) IL-5–transgenic mice. The level of eosinophils in Peyer's patches was determined by immunohistochemical staining with anti-MBP, followed by morphometric analysis and represented as mean ± SEM (n = 8-11). Statistical significance of experimental groups was analyzed using the unpaired Student t test. Normalization of Peyer's patch eosinophils per mm2 resulted in 0.62 ± 0.39 and 90 ± 25 (mean ± SEM, n = 8-14) eosinophils/mm2for wild-type and IL-5–transgenic mice, respectively.
