Fig. 3.
Effect of pharmacologic administration of IL-5 on eosinophils in the blood and Peyer's patches.
Saline alone or containing IL-5 (500 or 1000 pmol/kg) was delivered to mice via a mini-osmotic pump. The level of eosinophils in the blood (A) and Peyer's patches (B) was determined after 8 days. The number of MBP immunopositive cells is expressed as MBP per area (%) by morphometric analysis and represented as mean ± SEM (n = 6-8). The statistical significance of experimental groups was analyzed using the unpaired Student t test. Normalization of Peyer's patch eosinophils per mm2 resulted in 0.79 ± 0.36, 1.96 ± 0.93, and 12.3 ± 7.0 (mean ± SEM, n = 5-7) eosinophils/mm2 after saline and 500 and 1000 pmol of IL-5, respectively.
