Family pedigree and coagulation laboratory data.

The propositus is subject II4 (arrow). Open circle, FV Leiden (R506Q); gray circle, FV R2 (H1299R); closed circle, FV defect (Y1702C); open triangle, PT 20210G/A. Symptomatic family members are hatched. The numbers reported below each family member express the FV antigen and activity levels (normal range, 70%-130%), the normalized APC ratio (APC resistance is defined by an APC ratio less than 0.84), the PT antigen and activity levels (normal range, 75%-125% and 80%-120%, respectively), and the F1 + 2 values in nmol/L (normal range, 0.4-1.1 nmol/L), respectively.