Mcl-1 expression following chimeric Mcl-1 AS treatments.

PMA-stimulated U937 cells were treated with chimeric AS molecules, and RNA and protein samples were collected 4 and 18 hours after AS treatment. (A) Mcl-1 and actin mRNA and (B) protein were analyzed by Northern and Western blotting. The blots shown are representative of 3 independent experiments. Significant difference from controls treated only with SL-O is indicated by a dagger (P ≤ .05) or an asterisk (P ≤ .01).