Fig. 5.
![Fig. 5. IL-4 induces the proliferation of BMMCs through γc- and Jak3-dependent signaling. / BMMCs from WT, γc−, and Jak3−mice were cultured in the presence of IL-3 for 36 hours, with [3H] thymidine added for the final 12 hours. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs (IL-3 alone) in WT mice. *P < .005.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/96/6/10.1182_blood.v96.6.2172/5/h81800149005.jpeg?Expires=1742859198&Signature=3KMmCQ~q3fFT~KXCjcFB0El1yYjx5ztGYF81CVLEc2k4Je-e-WfkNPm1WYIMoR8tZ3MlyFP21Ow21~yzGRkM0wPKv5pO3q1EU1FNZpCXtS2ZJHtJKOZIos2BlszXwqgWhCfi02QZTJqVsWY~Z2pWvGcY~R9R3D8G6veb00bESkIVywp8YimEjOrl1O1JAaLyditVEqY30d4uT2OuK-Z6MCSTdRs0EnD6b9VLK3cawjxs5Q251A7HiV71BlJlMPexNJv5kVuQM7Gzl5U4Mu8iIyRJBunTfta89Na1XHrGcyH6iJdK1Tfzww1Kg-kNi9WDS7WzISwEi4sbrCxa5iG5Qg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
IL-4 induces the proliferation of BMMCs through γc- and Jak3-dependent signaling.
BMMCs from WT, γc−, and Jak3−mice were cultured in the presence of IL-3 for 36 hours, with [3H] thymidine added for the final 12 hours. Where indicated, recombinant murine IL-4 or recombinant murine IL-13 was added at 20 ng/mL. Data are means ± SD for 5 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of control BMMCs (IL-3 alone) in WT mice. *P < .005.
