Fig. 7.
Fig. 7. IL-4 induces the degranulation of BMMCs through γc- and Jak3-dependent signaling. / BMMCs from WT, γc−, and Jak3−mice were cultured for 4 days in the presence of IL-3 alone or IL-3 plus murine IL-4 (20 ng/mL). BMMCs were then stimulated with A23187 (200 ng/mL) for 30 minutes, and the percentage of specific β-hexosaminidase release was determined as described in “Materials and methods.” Data are means ± SD for 4 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of the corresponding BMMCs without IL-4 stimulation in WT mice. *P < .01.

IL-4 induces the degranulation of BMMCs through γc- and Jak3-dependent signaling.

BMMCs from WT, γc−, and Jak3−mice were cultured for 4 days in the presence of IL-3 alone or IL-3 plus murine IL-4 (20 ng/mL). BMMCs were then stimulated with A23187 (200 ng/mL) for 30 minutes, and the percentage of specific β-hexosaminidase release was determined as described in “Materials and methods.” Data are means ± SD for 4 mice in each group. The mean value of IL-4–stimulated BMMCs is significantly different from the mean value of the corresponding BMMCs without IL-4 stimulation in WT mice. *P < .01.

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