Effects of MMuLV insertions on the

Notch1 gene, transcripts, and protein products.(A) Disruption of Notch1 exonic sequences by the MMuLV proviral genome is shown schematically. Structures of mutatedNotch1 transcripts that could potentially result from integration into Notch1 exons are shown below. (B) Predicted Notch1 protein products resulting from 2 types of retroviral insertions in thymic lymphomas are compared with wild-type Notch1. Notch 3′ deletions remove all of PEST domain and varying portions of the transactivation domain reported by Kurooka et al.42