Mutations in severe congenital neutropenia.

Tertiary distribution of the severe congenital neutropenia (SCN) mutations (yellow) are compared to cyclic neutropenia/cyclic hematopoiesis (CH) mutations (red). Catalytic serine residue 173 is indicated in green near the active site pocket. The 2 figures are rotated 180° with respect to each other. The image was prepared from x-ray crystallographic coordinates taken from the Molecular Modeling DataBase (http://www.ncbi.nlm.nih.gov/Structure/MMDB/mmdb.html).