Ribbon diagram of neutrophil elastase with schematic representation of beta strands in complex with a peptide methoxysuccinyl-Ala-Ala-Pro-Ala chloromethyl ketone inhibitor.

Purple balls and chain fragment represent missense and deletion mutations. Red balls represent positions of truncation mutations in congenital neutropenia (A) and cyclic neutropenia (B). See text for explanations of effects of mutations noted. Drawing by E. Adman, University of Washington, using MOLSCRIPT (P. Kraulis. Molscript: a program to produce both detailed and schematic plots of protein structure. J Appl Crystallogr. 1991;24:946-950) and Raster3D (Merritt EA, Murphy MEP. Raster3D Version 2.0 a program for photorealistic molecular graphics. Acta Cyrstallogr. 1994;D50:869-873).