Induction of PAF-dependent hypothermia by anti-GPIIbIIIa but not other mAbs.

(A) Mice received 100 μg purified mAb. The mean values of the maximum change of body temperatures of 6 mice per group within 2 hours after injection of the antibodies are given ± SD. The number of survivors per group is shown on the left. (B) Mice received 1 mg/kg WEB2170 BS or PBS and 1 hour later 100 μg purified mAb intravenously in 200 μL sterile PBS. The mean values of the body temperatures of 6 mice per group at the indicated times after injection of the antibodies are given ± SD. (C) Platelet counts were determined at t = 6 hour, using an improved Neubauer hemocytometer. Results are expressed as the mean platelet count ± SD for groups of 6 mice each.