Fig. 5.
Importance of the Fc part of anti-GPIIbIIIa and anti-GPIbα.
(A) Mice received 100 μg purified mAb (or F(ab)2fragments) intravenously in 200 μL sterile PBS. The mean values of the body temperatures of 6 mice per group at the indicated times after injection of the antibodies are given ± SD. (B) Platelet counts were determined at t = 6 hours, using an improved Neubauer hemocytometer. Results are shown as the mean platelet count ± SD for groups of 6 mice each. (C, D) Mice (3 per group) received the indicated amounts of purified mAb or F(ab)2 fragments intravenously. Platelet counts were determined at t = 6 hours, using an improved Neubauer hemocytometer.
