Fucoidan-induced hematopoietic progenitor mobilization in wild-type and endothelial selectin-deficient mice.

(A), E−/− mice were administered 6 doses (25 mg/kg ip) of fucoidan or vehicle (PBS) over 2 days. Two hours after the last dose, circulating hematopoietic progenitors were assayed. n = 4. (B), Mice were injected with 2 doses (25 mg/kg) of fucoidan (FUC) or PBS over 6 hours. Numbers of circulating progenitors in WT, E−/−, and P/E−/− mice, n = 3-10, *P < .05; #P < .002.