P2cyc-induced aggregation occurs without degranulation in Gαq-deficient platelets.

TEM of WT (left panels) and Gαq-deficient mouse platelets (right panels) stimulated with 100 μmol/L ADP in the presence (panel B) or absence (panel A) of adrenaline (10 μmol/L). Secretion did not occur in WT or Gαq-deficient platelets, while shape change was blocked only in Gαq-deficient mouse platelets.