Time course of ancrod treatment of all 12 subjects (mean, SD, 95th percentile).

(A) Soluble fibrin complexes measured by Chromogenix SF. (B) Soluble fibrin complexes measured by immunologic test Fibrinostika SF. Both assays displayed a rather similar course, with a steady increase during the 6-hour ancrod infusion, followed by a gradual decrease. (C) TpP ELISA. This assay differed from the other soluble fibrin assays, showing a more extended course with a plateau between 6 and 24 hours after start of ancrod infusion, resembling the response of fibrin(ogen) degradation product assays.